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Results Cystine availability regulates mTORC1 signaling and the ISR We studied the effect of cystine starvation in HepG2 cells, which do not synthesize cysteine from methionine, to exclude the confounding effect of methionine 20

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The bulk of DSIP research was conducted between roughly 1977 and 1990 using methodology and statistical standards that would not meet current trial quality thresholds